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KMID : 0350519960490030947
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Journal of Catholic Medical College
1996 Volume.49 No. 3 p.947 ~ p.960
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The PCNA Gene Expression related to p53 Gene Mutation in Human Colorectal Carcinoma Cell Lines
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Abstract
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Inactivation of p53 gene is a common event in the development of human neoplasia. A variety of mechanism can lead to such functional inactivation, including missense mutation and interaction with oncogenic viral or cellular protein.
@ES The results are as follows:
@EN 1. In the protein expression of p53 and PCNA by immunofluorescein staining, SW-837 cell lines which express mutant p53 gene reveal positive expression above 76% of p53 and PCNA protein, SW-1463 cell lines which express mutant p53 gene reveal
positive above 76% of p53 protein and average 72.4 % of PCNA protein, LoVo cell which express weld-type p53 gene reveal positive expression average 17.5% of p53 protein and 28.3 % of PCNA protein and SW-1222 cell lines which do not express p53
gene
reveal negative expression.
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KEYWORD
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FullTexts / Linksout information
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Listed journal information
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